Name | methyl (2alpha,5alpha,19E)-1,2-dihydro-2,5-epoxyakuammilan-17-oate |
Synonyms | Picrinin Picrinine GenericnaMe methyl 1,2-dihydro-2,5-epoxyakuammilan-17-oate 2Α,5Α-Epoxy-1,2-Dihydroakuammilan-17-Oic Acid Methyl Ester 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Methyl (2alpha,5alpha,19E)-1,2-dihydro-2,5-epoxyakuammilan-17-oate methyl (2alpha,5alpha,19E)-1,2-dihydro-2,5-epoxyakuammilan-17-oate Methyl (2alpha,5alpha,15alpha,16xi,19E)-1,2-dihydro-2,5-epoxyakuammilan-17-oate 2H,12H-6,12A-Epoxy-2,7A-methanoindolo[2,3-A]quinolizine-14-carboxylic acid, 3-ethylidene-1,3,4,6,7,12B-hexahydro-, methyl ester, (2S,3E,6S,12ar,12bs)- 2H,12H-6,12a-epoxy-2,7a-methanoindolo[2,3-a]quinolizine-14-carboxylic acid, 3-ethylidene-1,3,4,6,7,12b-hexahydro-, methyl ester, (2R,3E,6S,7aR,12aR,12bS)- |
CAS | 4684-32-6 |
InChI | InChI=1/C20H22N2O3/c1-3-11-10-22-15-8-12(11)17(18(23)24-2)19-9-16(22)25-20(15,19)21-14-7-5-4-6-13(14)19/h3-7,12,15-17,21H,8-10H2,1-2H3/b11-3-/t12-,15-,16-,17?,19-,20-/m0/s1 |
Molecular Formula | C20H22N2O3 |
Molar Mass | 338.41 |
Density | 1.38±0.1 g/cm3(Predicted) |
Melting Point | 222-224 °C |
Boling Point | 501.1±50.0 °C(Predicted) |
Specific Rotation(α) | -44 (CHCl3) |
Flash Point | 256.864°C |
Solubility | Soluble in acidic solvents. |
Vapor Presure | 0mmHg at 25°C |
Appearance | White solid |
pKa | 4.47±0.40(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.677 |
overview | duck foot tree leaf alkali is a colorless needle-like crystal, easily soluble in methanol, chloroform, acetone, soluble in ethyl acetate, ethanol, insoluble in water and petroleum ether; Easily soluble in dilute hydrochloric acid and dilute sulfuric acid, after adding alkali and neutralizing, the solution becomes turbid and then precipitates again. |
use | duck foot leaf alkali (Picrinine) has therapeutic effect on cold, fever and respiratory diseases caused by it. Pharmacological and pharmacodynamic tests have proved that Duck's leaf alkaloids have significant antitussive, antiasthmatic, expectorant, anti-inflammatory and analgesic activities. Ducklefoot leaf alkali also has a very significant inhibitory effect on phase II pain response, but has no obvious effect on phase I pain. |
application | duck foot leaf alkali has obvious antitussive, antiasthmatic, expectorant, anti-inflammatory and analgesic activities, and is an active ingredient in sugar gum tree with high content, accounting for about 0.1% of medicinal materials. It can be used for quality index control in the preparation of drugs for the treatment of colds, fever and respiratory diseases caused by them. Ducklefoot leaf alkaline has a therapeutic effect on colds, fever and the respiratory diseases caused by it. |
preparation | pulverize the leaves of the lampstand into particles, take 10kg, percolate with 15 times the amount of 1% sulfuric acid aqueous solution, filter the extract through the hollow cellulose ultrafiltration membrane with 2000 molecular weight cut-off, add the hollow cellulose nanofiltration membrane with 300 molecular weight cut-off into the permeate to concentrate, pass through the AB 8 macroporous resin column, and elute with appropriate amount of water, collect the lower column liquid and washing liquid and adjust pH9 with ammonia water, place the precipitate, centrifuge, dissolve the precipitate with 90% methanol, dissolve and reflux, add 1% of the solution amount of activated carbon to decolorize, the decolorize liquid to filter out activated carbon, add 1/10 volume of petroleum ether, fully stir and refrigerate for crystallization, the crystal is recrystallized with 70% ethanol solution, and dry to obtain white crystals, that is, 15g of duck foot leaf alkali, and the content detection is 90.5%. |